The study involves quantitative analysis of ten different brands of paracetamol 500mg tablets, using Ultra violet Spectrophotometry method. The samples were dissolved in 0.1M NaOH and distilled water and their various absorbances were determined at wavelength of 257nm. The results obtained were read off the graph (standard curve) prepared from pure samples of paracetamol. Percentage content for each sample was calculated using absorbance’s gotten from spectrophotometry method, to deduce if it is within the specified limit by official books (90%-105% according to British Pharmacopoeia). The percentage content of the analyzed samples using UV Spectrophotometry method ranges from 84.32%-104.93%, indicating that none of the samples contains less than 80% of the active principle. It was observed that seven samples (NGC, Paingo, Fidson, Bonadol, Suremol, Painkill and M&B) out of the Ten Samples met the Standard limit of the British Phamacopoeia, whereas three samples (Easadol, Josedol and Emzor) were below the standard limit.
Belay, S., Garrigues, A.M., Rubio, T. and Guardia, M.D. (1996). Analytical Chim Acta. Pg: 330, 59-69.
Fujii, B.L., Lieb, K., Hull, M., Aicher, B., Ryn, J.V., Pairet, M. and Engelhardt, G. (2009). Effects of caffeine and parace-tamol alone or in combination with acetylsalicylic acid on prostaglandin E2 synthesis in rat microglial cells. Neuro-pharmacology. 39:22052213.
Taylor, K.S., Page, J. and Mackenney, P. (2009). Can intravenous paracetamol reduce opioid use in preoperative hip fracture patients? Ortho-pedics. 36: 20–24
Uddin, G., Rauf, A., Rehman, T. and Qaisar, M. (2011). Phytochemical screening of Pistaciachinensis var. integerrima. Middle East Journal of Scientific Research.;7: 707– 711.
WHO, (2007). “Cannabinoid‐based medicines for neurological disorders—clinical evidence.” Molecular neurobiology, 1: 129–136.
You can add your publications with LOJAS.Find Out
Get answers and advice from people you want it from.